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Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes

Rap1 GTPases control immune synapse formation and signaling in lymphocytes. However, the precise molecular mechanism by which Rap1 regulates natural killer (NK) cell activation is not known. Using Rap1a or Rap1b knockout mice, we identify Rap1b as the major isoform in NK cells. Its absence significa...

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Detalles Bibliográficos
Autores principales:	Awasthi, Aradhana, Samarakoon, Asanga, Chu, Haiyan, Kamalakannan, Rajasekaran, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, White, Gilbert C., Malarkannan, Subramaniam
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931159/ https://www.ncbi.nlm.nih.gov/pubmed/20733035 http://dx.doi.org/10.1084/jem.20100040

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