A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets. Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were generated by breeding FlnA(loxP/loxP) females with GATA1-Cre males. Fln...

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Detalles Bibliográficos
Autores principales: Falet, Hervé, Pollitt, Alice Y., Begonja, Antonija Jurak, Weber, Sarah E., Duerschmied, Daniel, Wagner, Denisa D., Watson, Steve P., Hartwig, John H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931168/
https://www.ncbi.nlm.nih.gov/pubmed/20713593
http://dx.doi.org/10.1084/jem.20100222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931168/
https://www.ncbi.nlm.nih.gov/pubmed/20713593
http://dx.doi.org/10.1084/jem.20100222

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