IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

Regulatory T cells (T reg cells) play a major role in controlling the pathogenic autoimmune process in type 1 diabetes (T1D). Interleukin 2 (IL-2), a cytokine which promotes T reg cell survival and function, may thus have therapeutic efficacy in T1D. We show that 5 d of low-dose IL-2 administration...

Descripción completa

Detalles Bibliográficos
Autores principales: Grinberg-Bleyer, Yenkel, Baeyens, Audrey, You, Sylvaine, Elhage, Rima, Fourcade, Gwladys, Gregoire, Sylvie, Cagnard, Nicolas, Carpentier, Wassila, Tang, Qizhi, Bluestone, Jeffrey, Chatenoud, Lucienne, Klatzmann, David, Salomon, Benoît L., Piaggio, Eliane
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931175/
https://www.ncbi.nlm.nih.gov/pubmed/20679400
http://dx.doi.org/10.1084/jem.20100209

Ejemplares similares

Ejemplares similares