Breast cancer heterogeneity: mechanisms, proofs, and implications

Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically distinct subtypes with substantially different molecular and/or biochemical signatures, clinical courses, and prognoses. This study analyzed the possible correlation between the morphologica...

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Detalles Bibliográficos
Autores principales: Hsiao, Yi-Hsuan, Chou, Ming-Chih, Fowler, Carol, Mason, Jeffrey T., Man, Yan-gao
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931354/
https://www.ncbi.nlm.nih.gov/pubmed/20842218
Descripción
Sumario:Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically distinct subtypes with substantially different molecular and/or biochemical signatures, clinical courses, and prognoses. This study analyzed the possible correlation between the morphological presentations of breast cancer and two hypothesized models of carcinogenesis, in order to identify the intrinsic mechanism(s) and clinical implications of breast cancer heterogeneity.

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