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Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study

BACKGROUND: The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type 2 diabetes (T2D). Even though knowledge about methodology is of highest import...

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Autores principales: Lundby-Christensen, Louise, Almdal, Thomas P, Carstensen, Bendix, Tarnow, Lise, Wiinberg, Niels
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931499/
https://www.ncbi.nlm.nih.gov/pubmed/20727128
http://dx.doi.org/10.1186/1475-2840-9-40
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author Lundby-Christensen, Louise
Almdal, Thomas P
Carstensen, Bendix
Tarnow, Lise
Wiinberg, Niels
author_facet Lundby-Christensen, Louise
Almdal, Thomas P
Carstensen, Bendix
Tarnow, Lise
Wiinberg, Niels
author_sort Lundby-Christensen, Louise
collection PubMed
description BACKGROUND: The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type 2 diabetes (T2D). Even though knowledge about methodology is of highest importance in order to make accurate power calculations and analyses of results, no reproducibility studies have been performed in this group of patients. The aim of this study was to quantify the variability of the measurement of carotid IMT in individuals with and without T2D. METHODS: We used B-mode ultrasound and a computerized software programme (MIA vascular tools) for analysis of carotid IMT. Measurement of carotid IMT in the far wall of the common carotid artery (CCA) was done for 30 patients with T2D and 30 persons without T2D. The examinations were done by two different sonographers and two different readers on two separate days in order to quantify sonographer-, reader-, and day-to-day variability. RESULTS: Comparisons of measurement of carotid IMT in CCA between sonographers (sonographer variability) resulted in limits of agreement (LoA) from -0.18 to 0.13 mm for patients with T2D and -0.12 to 0.10 mm for persons without T2D. This means, that a second scanning of the same person with 95% probability would be within this interval of the first scanning. Comparisons between readers assessing the same scanning (reader variability) resulted in LoA from -0.05 to 0.07 mm and -0.04 to 0.05 mm respectively. LoA of the day-to-day variability was -0.13 to 0.18 mm and -0.09 to 0.18 mm respectively. This corresponds to coefficients of variations (CV) of the sonographer- and day-to-day variability of 10% in patients with T2D and 8% in persons without T2D. The CV of the reader variability was 4% and 3% respectively. CONCLUSION: Measurement of carotid IMT in the CCA can be determined with good and comparable reproducibility in both patients with T2D and persons without T2D. These findings support the use of carotid IMT in clinical trials with T2D patients and suggest that the numbers of patients needed to detect a given difference will be the same whether the patients have T2D or not.
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spelling pubmed-29314992010-09-02 Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study Lundby-Christensen, Louise Almdal, Thomas P Carstensen, Bendix Tarnow, Lise Wiinberg, Niels Cardiovasc Diabetol Methodology BACKGROUND: The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type 2 diabetes (T2D). Even though knowledge about methodology is of highest importance in order to make accurate power calculations and analyses of results, no reproducibility studies have been performed in this group of patients. The aim of this study was to quantify the variability of the measurement of carotid IMT in individuals with and without T2D. METHODS: We used B-mode ultrasound and a computerized software programme (MIA vascular tools) for analysis of carotid IMT. Measurement of carotid IMT in the far wall of the common carotid artery (CCA) was done for 30 patients with T2D and 30 persons without T2D. The examinations were done by two different sonographers and two different readers on two separate days in order to quantify sonographer-, reader-, and day-to-day variability. RESULTS: Comparisons of measurement of carotid IMT in CCA between sonographers (sonographer variability) resulted in limits of agreement (LoA) from -0.18 to 0.13 mm for patients with T2D and -0.12 to 0.10 mm for persons without T2D. This means, that a second scanning of the same person with 95% probability would be within this interval of the first scanning. Comparisons between readers assessing the same scanning (reader variability) resulted in LoA from -0.05 to 0.07 mm and -0.04 to 0.05 mm respectively. LoA of the day-to-day variability was -0.13 to 0.18 mm and -0.09 to 0.18 mm respectively. This corresponds to coefficients of variations (CV) of the sonographer- and day-to-day variability of 10% in patients with T2D and 8% in persons without T2D. The CV of the reader variability was 4% and 3% respectively. CONCLUSION: Measurement of carotid IMT in the CCA can be determined with good and comparable reproducibility in both patients with T2D and persons without T2D. These findings support the use of carotid IMT in clinical trials with T2D patients and suggest that the numbers of patients needed to detect a given difference will be the same whether the patients have T2D or not. BioMed Central 2010-08-20 /pmc/articles/PMC2931499/ /pubmed/20727128 http://dx.doi.org/10.1186/1475-2840-9-40 Text en Copyright ©2010 Lundby-Christensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Lundby-Christensen, Louise
Almdal, Thomas P
Carstensen, Bendix
Tarnow, Lise
Wiinberg, Niels
Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title_full Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title_fullStr Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title_full_unstemmed Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title_short Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
title_sort carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931499/
https://www.ncbi.nlm.nih.gov/pubmed/20727128
http://dx.doi.org/10.1186/1475-2840-9-40
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