Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolut...

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Detalles Bibliográficos
Autores principales: Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen, Ndung'u, Thumbi, Goulder, Philip J. R., Walker, Bruce D., Brander, Christian, Heckerman, David E., Mullins, James I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931691/
https://www.ncbi.nlm.nih.gov/pubmed/20824187
http://dx.doi.org/10.1371/journal.pone.0012463

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