Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest

HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that Vpr performs this activity by recruiting the DDB1-CUL4A (VPRBP) E3 ubiquitin ligase. While recruitment of this E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Belzile, Jean-Philippe, Abrahamyan, Levon G., Gérard, Francine C. A., Rougeau, Nicole, Cohen, Éric A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932712/
https://www.ncbi.nlm.nih.gov/pubmed/20824083
http://dx.doi.org/10.1371/journal.ppat.1001080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932712/
https://www.ncbi.nlm.nih.gov/pubmed/20824083
http://dx.doi.org/10.1371/journal.ppat.1001080

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