Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner

Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes present in virions. Here we reveal a fundamental difference between...

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Detalles Bibliográficos
Autores principales: Köck, Josef, Rösler, Christine, Zhang, Jing-Jing, Blum, Hubert E., Nassal, Michael, Thoma, Christian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932716/
https://www.ncbi.nlm.nih.gov/pubmed/20824087
http://dx.doi.org/10.1371/journal.ppat.1001082

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