The Canine Papillomavirus and Gamma HPV E7 Proteins Use an Alternative Domain to Bind and Destabilize the Retinoblastoma Protein

The high-risk HPV E6 and E7 proteins cooperate to immortalize primary human cervical cells and the E7 protein can independently transform fibroblasts in vitro, primarily due to its ability to associate with and degrade the retinoblastoma tumor suppressor protein, pRb. The binding of E7 to pRb is med...

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Detalles Bibliográficos
Autores principales: Wang, Jingang, Zhou, Dan, Prabhu, Anjali, Schlegel, Richard, Yuan, Hang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932728/
https://www.ncbi.nlm.nih.gov/pubmed/20824099
http://dx.doi.org/10.1371/journal.ppat.1001089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932728/
https://www.ncbi.nlm.nih.gov/pubmed/20824099
http://dx.doi.org/10.1371/journal.ppat.1001089

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