Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous Recombination

Topoisomerase II (Top2) is a nuclear enzyme involved in several metabolic processes of DNA. Chemotherapy agents that poison Top2 are known to induce persistent protein-mediated DNA double strand breaks (DSB). In this report, by using knock down experiments, we demonstrated that Top2α was largely res...

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Detalles Bibliográficos
Autores principales: de Campos-Nebel, Marcelo, Larripa, Irene, González-Cid, Marcela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932731/
https://www.ncbi.nlm.nih.gov/pubmed/20824055
http://dx.doi.org/10.1371/journal.pone.0012541

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