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Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

BACKGROUND: Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endothelial cells through the hypoxic tumour tissue. Cat...

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Detalles Bibliográficos
Autores principales:	Ward, Claire, Kuehn, Diana, Burden, Roberta E., Gormley, Julie A., Jaquin, Thomas J., Gazdoiu, Mihaela, Small, Donna, Bicknell, Roy, Johnston, James A., Scott, Christopher J., Olwill, Shane A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932732/ https://www.ncbi.nlm.nih.gov/pubmed/20824056 http://dx.doi.org/10.1371/journal.pone.0012543

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