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Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2

Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO(2) and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. We found that ME2 is expressed in K562 erythroleukemia cells, in which a nu...

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Detalles Bibliográficos
Autores principales:	Ren, Jian-Guo, Seth, Pankaj, Everett, Peter, Clish, Clary B., Sukhatme, Vikas P.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932743/ https://www.ncbi.nlm.nih.gov/pubmed/20824065 http://dx.doi.org/10.1371/journal.pone.0012520

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