Cargando…

The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence

OBJECTIVE: The effects of sevoflurane general anesthesia and bupivacaine selective spinal anesthesia on QT dispersion (QTd) and corrected QT (QTc) interval were investigated. METHODS AND MATERIALS: This prospective, randomized, double-blind study was conducted between July and September 2009 in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ornek, Ender, Ornek, Dilsen, Alkent, Z Peren, Ekin, Abdülselam, Basaran, Meleksah, Dikmen, Bayazit
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933124/
https://www.ncbi.nlm.nih.gov/pubmed/20835552
http://dx.doi.org/10.1590/S1807-59322010000800005
_version_ 1782186119320829952
author Ornek, Ender
Ornek, Dilsen
Alkent, Z Peren
Ekin, Abdülselam
Basaran, Meleksah
Dikmen, Bayazit
author_facet Ornek, Ender
Ornek, Dilsen
Alkent, Z Peren
Ekin, Abdülselam
Basaran, Meleksah
Dikmen, Bayazit
author_sort Ornek, Ender
collection PubMed
description OBJECTIVE: The effects of sevoflurane general anesthesia and bupivacaine selective spinal anesthesia on QT dispersion (QTd) and corrected QT (QTc) interval were investigated. METHODS AND MATERIALS: This prospective, randomized, double-blind study was conducted between July and September 2009 in the Urology and General Surgery operating rooms. Forty ASA I–II patients undergoing noncardiac surgery were randomized into two groups: Group R (n = 20) and Group V (n = 20). In Group R, 5 mg bupivacaine was administered into the spinal space. Anesthesia induction in Group V was established with sevoflurane + 0.1 mg/kg vecuronium using the maximum vital capacity technique. Anesthesia was maintained with 2–3% sevoflurane + 50% N(2)O/O(2) inhalation. All patients were tested with a 24-hour Holter ECG device. QT, QTc, and QTd intervals were measured using 12-lead ECG records at 1 and 3 minutes during preinduction, postinduction, postincision and postextubation periods. Mean arterial pressure (MAP), heart rate and ECG records were measured simultaneously. RESULTS: None of the patients displayed arrhythmia. There was no significant difference between the groups with regard to QTd values (p>0.05). However, QTc was longer in Group V than in Group R after the induction of anesthesia at 3 minutes, after the intubation at 1 and 3 minutes, and after the incision at 1 and 3 minutes. MAP and heart rate were generally higher in Group V (p<0.05). CONCLUSION: Although Volatile Induction and Maintenance of Anesthesia (VIMA) with sevoflurane might prolong the QTc interval and did not result in arrhythmia, selective spinal anesthesia with bupivacaine was not associated with alterations in the QT interval or arrhythmia.
format Text
id pubmed-2933124
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-29331242010-09-13 The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence Ornek, Ender Ornek, Dilsen Alkent, Z Peren Ekin, Abdülselam Basaran, Meleksah Dikmen, Bayazit Clinics (Sao Paulo) Clinical Science OBJECTIVE: The effects of sevoflurane general anesthesia and bupivacaine selective spinal anesthesia on QT dispersion (QTd) and corrected QT (QTc) interval were investigated. METHODS AND MATERIALS: This prospective, randomized, double-blind study was conducted between July and September 2009 in the Urology and General Surgery operating rooms. Forty ASA I–II patients undergoing noncardiac surgery were randomized into two groups: Group R (n = 20) and Group V (n = 20). In Group R, 5 mg bupivacaine was administered into the spinal space. Anesthesia induction in Group V was established with sevoflurane + 0.1 mg/kg vecuronium using the maximum vital capacity technique. Anesthesia was maintained with 2–3% sevoflurane + 50% N(2)O/O(2) inhalation. All patients were tested with a 24-hour Holter ECG device. QT, QTc, and QTd intervals were measured using 12-lead ECG records at 1 and 3 minutes during preinduction, postinduction, postincision and postextubation periods. Mean arterial pressure (MAP), heart rate and ECG records were measured simultaneously. RESULTS: None of the patients displayed arrhythmia. There was no significant difference between the groups with regard to QTd values (p>0.05). However, QTc was longer in Group V than in Group R after the induction of anesthesia at 3 minutes, after the intubation at 1 and 3 minutes, and after the incision at 1 and 3 minutes. MAP and heart rate were generally higher in Group V (p<0.05). CONCLUSION: Although Volatile Induction and Maintenance of Anesthesia (VIMA) with sevoflurane might prolong the QTc interval and did not result in arrhythmia, selective spinal anesthesia with bupivacaine was not associated with alterations in the QT interval or arrhythmia. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010-08 /pmc/articles/PMC2933124/ /pubmed/20835552 http://dx.doi.org/10.1590/S1807-59322010000800005 Text en Copyright © 2010 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Ornek, Ender
Ornek, Dilsen
Alkent, Z Peren
Ekin, Abdülselam
Basaran, Meleksah
Dikmen, Bayazit
The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title_full The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title_fullStr The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title_full_unstemmed The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title_short The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence
title_sort effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on qt interval, qt dispersion, and arrhythmia incidence
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933124/
https://www.ncbi.nlm.nih.gov/pubmed/20835552
http://dx.doi.org/10.1590/S1807-59322010000800005
work_keys_str_mv AT ornekender theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT ornekdilsen theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT alkentzperen theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT ekinabdulselam theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT basaranmeleksah theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT dikmenbayazit theeffectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT ornekender effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT ornekdilsen effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT alkentzperen effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT ekinabdulselam effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT basaranmeleksah effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence
AT dikmenbayazit effectsofvolatileinductionandmaintenanceofanesthesiaandselectivespinalanesthesiaonqtintervalqtdispersionandarrhythmiaincidence