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Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes

BACKGROUND: Anti-mitotic compounds (microtubule de-stabilizers) such as vincristine and vinblastine have been shown clinically successful in treating various cancers. However, development of drug-resistance cells limits their efficacies in clinical situations. Therefore, experiments were performed t...

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Detalles Bibliográficos
Autores principales:	Cheung, Chun Hei Antonio, Wu, Su-Ying, Lee, Tian-Ren, Chang, Chi-Yen, Wu, Jian-Sung, Hsieh, Hsing-Pang, Chang, Jang-Yang
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933234/ https://www.ncbi.nlm.nih.gov/pubmed/20838440 http://dx.doi.org/10.1371/journal.pone.0012564

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