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Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line
BACKGROUND: Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in accumulation of decarboxylated S-adenosylmethioni...
Autores principales: | Yamamoto, Daisuke, Shima, Kaori, Matsuo, Kou, Nishioka, Takashi, Chen, Chang Yan, Hu, Guo-fu, Sasaki, Akira, Tsuji, Takanori |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933235/ https://www.ncbi.nlm.nih.gov/pubmed/20838441 http://dx.doi.org/10.1371/journal.pone.0012554 |
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