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Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients

BACKGROUND: The 516G > T polymorphism in exon 4 of the CYP2B6 gene has been associated with increased plasma Efavirenz (EFV) concentrations. EFV concentrations greater than the recommended therapeutic range have been associated with the increased likelihood of developing adverse CNS effects. The...

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Detalles Bibliográficos
Autores principales:	Gounden, Verena, van Niekerk, Chantal, Snyman, Tracy, George, Jaya A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933581/ https://www.ncbi.nlm.nih.gov/pubmed/20723261 http://dx.doi.org/10.1186/1742-6405-7-32

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