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Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer

BACKGROUND: Previous reports have suggested that the appearance of pleural effusions (i.e., the presence or absence of blood) might help to establish the etiology of the effusions. This study explores the relationship between pleural fluid appearance and the results of chemical and cytological analy...

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Autores principales: Ozcakar, Bulent, Martinez, Carlos H, Morice, Rodolfo C, Eapen, Georgie A, Ost, David, Sarkiss, Mona G, Chiu, Hsienchang T, Jimenez, Carlos A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933602/
https://www.ncbi.nlm.nih.gov/pubmed/20718978
http://dx.doi.org/10.1186/1749-8090-5-63
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author Ozcakar, Bulent
Martinez, Carlos H
Morice, Rodolfo C
Eapen, Georgie A
Ost, David
Sarkiss, Mona G
Chiu, Hsienchang T
Jimenez, Carlos A
author_facet Ozcakar, Bulent
Martinez, Carlos H
Morice, Rodolfo C
Eapen, Georgie A
Ost, David
Sarkiss, Mona G
Chiu, Hsienchang T
Jimenez, Carlos A
author_sort Ozcakar, Bulent
collection PubMed
description BACKGROUND: Previous reports have suggested that the appearance of pleural effusions (i.e., the presence or absence of blood) might help to establish the etiology of the effusions. This study explores the relationship between pleural fluid appearance and the results of chemical and cytological analyses in a group of patients with recurrent symptomatic pleural effusions and a diagnosis of cancer. METHODS: Medical records were reviewed from all 390 patients who were diagnosed with cancer, who underwent thoracentesis before placement of an intrapleural catheter (IPC) between April 2000 and January 2006. Adequate information for data analysis was available in 365 patients. The appearance of their pleural fluid was obtained from procedure notes dictated by the pulmonologists who had performed the thoracenteses. The patients were separated into 2 groups based on fluid appearance: non-bloody and bloody. Group differences in cytology interpretation were compared by using the chi square test. Cellular counts, chemical laboratory results, and survival after index procedure were compared by using the student's t test. RESULTS: Pleural fluid cytology was positive on 82.5% of the non-bloody effusions and on 82.4% of the bloody ones. The number of red blood cells (220.5 × 10(3)/μL vs. 12.3 × 10(3)/μL) and LDH values (1914 IU/dl vs. 863 IU/dl) were statistically higher in bloody pleural effusions. CONCLUSION: The presence or absence of blood in pleural effusions cannot predict their etiology in patients with cancer and recurrent symptomatic pleural effusions.
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spelling pubmed-29336022010-09-07 Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer Ozcakar, Bulent Martinez, Carlos H Morice, Rodolfo C Eapen, Georgie A Ost, David Sarkiss, Mona G Chiu, Hsienchang T Jimenez, Carlos A J Cardiothorac Surg Research Article BACKGROUND: Previous reports have suggested that the appearance of pleural effusions (i.e., the presence or absence of blood) might help to establish the etiology of the effusions. This study explores the relationship between pleural fluid appearance and the results of chemical and cytological analyses in a group of patients with recurrent symptomatic pleural effusions and a diagnosis of cancer. METHODS: Medical records were reviewed from all 390 patients who were diagnosed with cancer, who underwent thoracentesis before placement of an intrapleural catheter (IPC) between April 2000 and January 2006. Adequate information for data analysis was available in 365 patients. The appearance of their pleural fluid was obtained from procedure notes dictated by the pulmonologists who had performed the thoracenteses. The patients were separated into 2 groups based on fluid appearance: non-bloody and bloody. Group differences in cytology interpretation were compared by using the chi square test. Cellular counts, chemical laboratory results, and survival after index procedure were compared by using the student's t test. RESULTS: Pleural fluid cytology was positive on 82.5% of the non-bloody effusions and on 82.4% of the bloody ones. The number of red blood cells (220.5 × 10(3)/μL vs. 12.3 × 10(3)/μL) and LDH values (1914 IU/dl vs. 863 IU/dl) were statistically higher in bloody pleural effusions. CONCLUSION: The presence or absence of blood in pleural effusions cannot predict their etiology in patients with cancer and recurrent symptomatic pleural effusions. BioMed Central 2010-08-18 /pmc/articles/PMC2933602/ /pubmed/20718978 http://dx.doi.org/10.1186/1749-8090-5-63 Text en Copyright ©2010 Ozcakar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ozcakar, Bulent
Martinez, Carlos H
Morice, Rodolfo C
Eapen, Georgie A
Ost, David
Sarkiss, Mona G
Chiu, Hsienchang T
Jimenez, Carlos A
Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title_full Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title_fullStr Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title_full_unstemmed Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title_short Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
title_sort does pleural fluid appearance really matter? the relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933602/
https://www.ncbi.nlm.nih.gov/pubmed/20718978
http://dx.doi.org/10.1186/1749-8090-5-63
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