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Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea

Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one o...

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Detalles Bibliográficos
Autores principales: Rother, Michael, Krzycki, Joseph A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933860/
https://www.ncbi.nlm.nih.gov/pubmed/20847933
http://dx.doi.org/10.1155/2010/453642
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author Rother, Michael
Krzycki, Joseph A.
author_facet Rother, Michael
Krzycki, Joseph A.
author_sort Rother, Michael
collection PubMed
description Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.
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spelling pubmed-29338602010-09-16 Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea Rother, Michael Krzycki, Joseph A. Archaea Review Article Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism. Hindawi Publishing Corporation 2010-08-17 /pmc/articles/PMC2933860/ /pubmed/20847933 http://dx.doi.org/10.1155/2010/453642 Text en Copyright © 2010 M. Rother and J. A. Krzycki. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rother, Michael
Krzycki, Joseph A.
Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title_full Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title_fullStr Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title_full_unstemmed Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title_short Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea
title_sort selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933860/
https://www.ncbi.nlm.nih.gov/pubmed/20847933
http://dx.doi.org/10.1155/2010/453642
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