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An animal model manifesting neurodegeneration and obesity
Although the existence of a link between neurodegenerative diseases and obesity has been suggested, a causal relation between neural degeneration and obesity has remained to be demonstrated experimentally. We recently showed that neurodegeneration in the hypothalamic satiety center results in obesit...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Impact Journals LLC
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933892/ https://www.ncbi.nlm.nih.gov/pubmed/20622266 |
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author | Susaki, Etsuo Nakayama, Keiichi I. |
author_facet | Susaki, Etsuo Nakayama, Keiichi I. |
author_sort | Susaki, Etsuo |
collection | PubMed |
description | Although the existence of a link between neurodegenerative diseases and obesity has been suggested, a causal relation between neural degeneration and obesity has remained to be demonstrated experimentally. We recently showed that neurodegeneration in the hypothalamic satiety center results in obesity in mice transgenic for E4B (also known as UFD2a), a mammalian ubiquitin elongation factor (E4). Increased expression of E4B in neurons of the transgenic mice results in the formation of ubiquitin-positive aggregates similar to those apparent in many human neurodegenerative diseases as well as in degeneration of hypothalamic neurons responsible for the regulation of food intake and energy expenditure. We thus propose that neurodegeneration is a possible cause of human obesity and related metabolic diseases, which have become a serious public health problem worldwide. Our animal model is thus a powerful tool for studies of the relation between neurodegeneration and obesity. |
format | Text |
id | pubmed-2933892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-29338922010-09-07 An animal model manifesting neurodegeneration and obesity Susaki, Etsuo Nakayama, Keiichi I. Aging (Albany NY) Research Perspective Although the existence of a link between neurodegenerative diseases and obesity has been suggested, a causal relation between neural degeneration and obesity has remained to be demonstrated experimentally. We recently showed that neurodegeneration in the hypothalamic satiety center results in obesity in mice transgenic for E4B (also known as UFD2a), a mammalian ubiquitin elongation factor (E4). Increased expression of E4B in neurons of the transgenic mice results in the formation of ubiquitin-positive aggregates similar to those apparent in many human neurodegenerative diseases as well as in degeneration of hypothalamic neurons responsible for the regulation of food intake and energy expenditure. We thus propose that neurodegeneration is a possible cause of human obesity and related metabolic diseases, which have become a serious public health problem worldwide. Our animal model is thus a powerful tool for studies of the relation between neurodegeneration and obesity. Impact Journals LLC 2010-07-08 /pmc/articles/PMC2933892/ /pubmed/20622266 Text en Copyright: ©2010 Susaki et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Perspective Susaki, Etsuo Nakayama, Keiichi I. An animal model manifesting neurodegeneration and obesity |
title | An animal model manifesting neurodegeneration and obesity |
title_full | An animal model manifesting neurodegeneration and obesity |
title_fullStr | An animal model manifesting neurodegeneration and obesity |
title_full_unstemmed | An animal model manifesting neurodegeneration and obesity |
title_short | An animal model manifesting neurodegeneration and obesity |
title_sort | animal model manifesting neurodegeneration and obesity |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933892/ https://www.ncbi.nlm.nih.gov/pubmed/20622266 |
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