Cargando…
Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mit...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933917/ https://www.ncbi.nlm.nih.gov/pubmed/20847946 http://dx.doi.org/10.1155/2010/937123 |
_version_ | 1782186200390434816 |
---|---|
author | Uguccioni, Giulia D'souza, Donna Hood, David A. |
author_facet | Uguccioni, Giulia D'souza, Donna Hood, David A. |
author_sort | Uguccioni, Giulia |
collection | PubMed |
description | PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1α. Posttranslational modifications also regulate the function of PGC-1α, with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1α in exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1α, as well as the role of the coactivator during exercise adaptations. |
format | Text |
id | pubmed-2933917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29339172010-09-16 Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise Uguccioni, Giulia D'souza, Donna Hood, David A. PPAR Res Review Article PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1α. Posttranslational modifications also regulate the function of PGC-1α, with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1α in exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1α, as well as the role of the coactivator during exercise adaptations. Hindawi Publishing Corporation 2010 2010-08-19 /pmc/articles/PMC2933917/ /pubmed/20847946 http://dx.doi.org/10.1155/2010/937123 Text en Copyright © 2010 Giulia Uguccioni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Uguccioni, Giulia D'souza, Donna Hood, David A. Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title | Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title_full | Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title_fullStr | Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title_full_unstemmed | Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title_short | Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise |
title_sort | regulation of pparγ coactivator-1α function and expression in muscle: effect of exercise |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933917/ https://www.ncbi.nlm.nih.gov/pubmed/20847946 http://dx.doi.org/10.1155/2010/937123 |
work_keys_str_mv | AT uguccionigiulia regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise AT dsouzadonna regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise AT hooddavida regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise |