Cargando…

Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise

PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mit...

Descripción completa

Detalles Bibliográficos
Autores principales: Uguccioni, Giulia, D'souza, Donna, Hood, David A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933917/
https://www.ncbi.nlm.nih.gov/pubmed/20847946
http://dx.doi.org/10.1155/2010/937123
_version_ 1782186200390434816
author Uguccioni, Giulia
D'souza, Donna
Hood, David A.
author_facet Uguccioni, Giulia
D'souza, Donna
Hood, David A.
author_sort Uguccioni, Giulia
collection PubMed
description PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1α. Posttranslational modifications also regulate the function of PGC-1α, with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1α in exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1α, as well as the role of the coactivator during exercise adaptations.
format Text
id pubmed-2933917
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-29339172010-09-16 Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise Uguccioni, Giulia D'souza, Donna Hood, David A. PPAR Res Review Article PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1α. Posttranslational modifications also regulate the function of PGC-1α, with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1α in exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1α, as well as the role of the coactivator during exercise adaptations. Hindawi Publishing Corporation 2010 2010-08-19 /pmc/articles/PMC2933917/ /pubmed/20847946 http://dx.doi.org/10.1155/2010/937123 Text en Copyright © 2010 Giulia Uguccioni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Uguccioni, Giulia
D'souza, Donna
Hood, David A.
Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title_full Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title_fullStr Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title_full_unstemmed Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title_short Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise
title_sort regulation of pparγ coactivator-1α function and expression in muscle: effect of exercise
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933917/
https://www.ncbi.nlm.nih.gov/pubmed/20847946
http://dx.doi.org/10.1155/2010/937123
work_keys_str_mv AT uguccionigiulia regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise
AT dsouzadonna regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise
AT hooddavida regulationofppargcoactivator1afunctionandexpressioninmuscleeffectofexercise