Cargando…

Maturation Mechanism of Severe Acute Respiratory Syndrome (SARS) Coronavirus 3C-like Proteinase

The 3C-like proteinase (3CL(pro)) of the severe acute respiratory syndrome (SARS) coronavirus plays a vital role in virus maturation and is proposed to be a key target for drug design against SARS. Various in vitro studies revealed that only the dimer of the matured 3CL(pro) is active. However, as t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chunmei, Qi, Yifei, Teng, Xin, Yang, Zongchang, Wei, Ping, Zhang, Changsheng, Tan, Lei, Zhou, Lu, Liu, Ying, Lai, Luhua
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934678/ https://www.ncbi.nlm.nih.gov/pubmed/20489209 http://dx.doi.org/10.1074/jbc.M109.095851

Ejemplares similares

Procollagen C-proteinase Enhancer Stimulates Procollagen Processing by Binding to the C-propeptide Region Only
por: Vadon-Le Goff, Sandrine, et al.
Publicado: (2011)

Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn
por: Korneeva, Vera A., et al.
Publicado: (2014)

The substrate specificity of SARS coronavirus 3C-like proteinase
por: Fan, Keqiang, et al.
Publicado: (2005)

Sequential and differential interaction of assembly factors during nitrogenase MoFe protein maturation
por: Jimenez-Vicente, Emilio, et al.
Publicado: (2018)

The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase()
por: Wei, Ping, et al.
Publicado: (2006)

The Roles of Family B and D DNA Polymerases in Thermococcus Species 9°N Okazaki Fragment Maturation
por: Greenough, Lucia, et al.
Publicado: (2015)

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
por: Bailey, Samuel S., et al.
Publicado: (2018)

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase
por: Fan, Keqiang, et al.
Publicado: (2004)

The interaction between severe acute respiratory syndrome coronavirus 3C-like proteinase and a dimeric inhibitor by capillary electrophoresis
por: Ding, Li, et al.
Publicado: (2005)

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2020)

High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
por: Lu, Jinghua, et al.
Publicado: (2020)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
por: Chen, Hao, et al.
Publicado: (2006)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
por: Singleton, Rachelle S., et al.
Publicado: (2011)

Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44
por: Ariza, Antonio, et al.
Publicado: (2011)

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex
por: Vorontsov, Ivan I., et al.
Publicado: (2011)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities
por: Bloemink, Marieke J., et al.
Publicado: (2011)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
por: Szeto, Mindy D., et al.
Publicado: (2011)

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
por: Ishizuka, Tomoko, et al.
Publicado: (2010)

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity
por: Schwendener, Sybille, et al.
Publicado: (2010)

Dynamic Mechanism of Proton Transfer in Mannitol 2-Dehydrogenase from Pseudomonas fluorescens: MOBILE GLU(292) CONTROLS PROTON RELAY THROUGH A WATER CHANNEL THAT CONNECTS THE ACTIVE SITE WITH BULK SOLVENT
por: Klimacek, Mario, et al.
Publicado: (2012)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex
por: Jin, Zhinan, et al.
Publicado: (2012)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

Kinetic Characterization of Single Strand Break Ligation in Duplex DNA by T4 DNA Ligase
por: Lohman, Gregory J. S., et al.
Publicado: (2011)

Cellulases Dig Deep: IN SITU OBSERVATION OF THE MESOSCOPIC STRUCTURAL DYNAMICS OF ENZYMATIC CELLULOSE DEGRADATION
por: Bubner, Patricia, et al.
Publicado: (2012)

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

Identification of Human Fumarylacetoacetate Hydrolase Domain-containing Protein 1 (FAHD1) as a Novel Mitochondrial Acylpyruvase
por: Pircher, Haymo, et al.
Publicado: (2011)

A Nucleotide Phosphatase Activity in the Nucleotide Binding Domain of an Orphan Resistance Protein from Rice
por: Fenyk, Stepan, et al.
Publicado: (2012)

The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues
por: Saino, Hiromichi, et al.
Publicado: (2011)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_pfk59rurbdpi5563qcacsdl6li