Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been found to have protective effects against multiple forms of damage in acute settings. The increase in longevity seen in response to...

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Detalles Bibliográficos
Autores principales: Bitto, Alessandro, Lerner, Chad, Torres, Claudio, Roell, Michaela, Malaguti, Marco, Perez, Viviana, Lorenzini, Antonello, Hrelia, Silvana, Ikeno, Yuji, Matzko, Michelle Elizabeth, McCarter, Roger, Sell, Christian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935370/
https://www.ncbi.nlm.nih.gov/pubmed/20830296
http://dx.doi.org/10.1371/journal.pone.0012592

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