RefProtDom: a protein database with improved domain boundaries and homology relationships

Summary: RefProtDom provides a set of divergent query domains, originally selected from Pfam, and full-length proteins containing their homologous domains, with diverse architectures, for evaluating pair-wise and iterative sequence similarity searches. Pfam homology and domain boundary annotations i...

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Detalles Bibliográficos
Autores principales: Gonzalez, Mileidy W., Pearson, William R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935417/
https://www.ncbi.nlm.nih.gov/pubmed/20693322
http://dx.doi.org/10.1093/bioinformatics/btq426
Descripción
Sumario:Summary: RefProtDom provides a set of divergent query domains, originally selected from Pfam, and full-length proteins containing their homologous domains, with diverse architectures, for evaluating pair-wise and iterative sequence similarity searches. Pfam homology and domain boundary annotations in the target library were supplemented using local and semi-global searches, PSI-BLAST searches, and SCOP and CATH classifications. Availability: RefProtDom is available from http://faculty.virginia.edu/wrpearson/fasta/PUBS/gonzalez09a Contact: miledywgonzalez@gmail.com; pearson@virginia.edu

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