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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
Mutations in human CEP290 cause cilia-related disorders that range in severity from isolated blindness to perinatal lethality. Here, we describe a Chlamydomonas reinhardtii mutant in which most of the CEP290 gene is deleted. Immunoelectron microscopy indicated that CEP290 is located in the flagellar...
Autores principales: | Craige, Branch, Tsao, Che-Chia, Diener, Dennis R., Hou, Yuqing, Lechtreck, Karl-Ferdinand, Rosenbaum, Joel L., Witman, George B. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935561/ https://www.ncbi.nlm.nih.gov/pubmed/20819941 http://dx.doi.org/10.1083/jcb.201006105 |
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