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Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

The inhibitory neurotransmitter γ-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system, GAD65 is transiently activated and augments...

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Detalles Bibliográficos
Autores principales:	Kanaani, Jamil, Kolibachuk, Julia, Martinez, Hugo, Baekkeskov, Steinunn
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935578/ https://www.ncbi.nlm.nih.gov/pubmed/20805323 http://dx.doi.org/10.1083/jcb.200912101

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