Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion

To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary e...

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Autores principales: Zhu, Hui-Feng, Wan, Dong, Luo, Yong, Zhou, Jia-Li, Chen, Li, Xu, Xiao-Yu
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935667/
https://www.ncbi.nlm.nih.gov/pubmed/20827397
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author Zhu, Hui-Feng
Wan, Dong
Luo, Yong
Zhou, Jia-Li
Chen, Li
Xu, Xiao-Yu
author_facet Zhu, Hui-Feng
Wan, Dong
Luo, Yong
Zhou, Jia-Li
Chen, Li
Xu, Xiao-Yu
author_sort Zhu, Hui-Feng
collection PubMed
description To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately.
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spelling pubmed-29356672010-09-08 Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion Zhu, Hui-Feng Wan, Dong Luo, Yong Zhou, Jia-Li Chen, Li Xu, Xiao-Yu Int J Biol Sci Research Paper To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately. Ivyspring International Publisher 2010-08-20 /pmc/articles/PMC2935667/ /pubmed/20827397 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Zhu, Hui-Feng
Wan, Dong
Luo, Yong
Zhou, Jia-Li
Chen, Li
Xu, Xiao-Yu
Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title_full Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title_fullStr Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title_full_unstemmed Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title_short Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
title_sort catalpol increases brain angiogenesis and up-regulates vegf and epo in the rat after permanent middle cerebral artery occlusion
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935667/
https://www.ncbi.nlm.nih.gov/pubmed/20827397
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