Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease

Leucine rich repeat kinase 2 (LRRK2) mutations are a common cause of Parkinson’s disease (PD). Here, we identify inhibitors of LRRK2 kinase, which are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in v...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Byoung Dae, Shin, Joo-Ho, VanKampen, Jackalina, Petrucelli, Leonard, West, Andrew B., Ko, Han Seok, Lee, Yun, Maguire-Zeiss, Kathleen A., Bowers, William J., Federoff, Howard J., Dawson, Valina L., Dawson, Ted M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935926/
https://www.ncbi.nlm.nih.gov/pubmed/20729864
http://dx.doi.org/10.1038/nm.2199
_version_ 1782186434292088832
author Lee, Byoung Dae
Shin, Joo-Ho
VanKampen, Jackalina
Petrucelli, Leonard
West, Andrew B.
Ko, Han Seok
Lee, Yun
Maguire-Zeiss, Kathleen A.
Bowers, William J.
Federoff, Howard J.
Dawson, Valina L.
Dawson, Ted M.
author_facet Lee, Byoung Dae
Shin, Joo-Ho
VanKampen, Jackalina
Petrucelli, Leonard
West, Andrew B.
Ko, Han Seok
Lee, Yun
Maguire-Zeiss, Kathleen A.
Bowers, William J.
Federoff, Howard J.
Dawson, Valina L.
Dawson, Ted M.
author_sort Lee, Byoung Dae
collection PubMed
description Leucine rich repeat kinase 2 (LRRK2) mutations are a common cause of Parkinson’s disease (PD). Here, we identify inhibitors of LRRK2 kinase, which are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of PD.
format Text
id pubmed-2935926
institution National Center for Biotechnology Information
language English
publishDate 2010
record_format MEDLINE/PubMed
spelling pubmed-29359262011-03-01 Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease Lee, Byoung Dae Shin, Joo-Ho VanKampen, Jackalina Petrucelli, Leonard West, Andrew B. Ko, Han Seok Lee, Yun Maguire-Zeiss, Kathleen A. Bowers, William J. Federoff, Howard J. Dawson, Valina L. Dawson, Ted M. Nat Med Article Leucine rich repeat kinase 2 (LRRK2) mutations are a common cause of Parkinson’s disease (PD). Here, we identify inhibitors of LRRK2 kinase, which are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of PD. 2010-08-22 2010-09 /pmc/articles/PMC2935926/ /pubmed/20729864 http://dx.doi.org/10.1038/nm.2199 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lee, Byoung Dae
Shin, Joo-Ho
VanKampen, Jackalina
Petrucelli, Leonard
West, Andrew B.
Ko, Han Seok
Lee, Yun
Maguire-Zeiss, Kathleen A.
Bowers, William J.
Federoff, Howard J.
Dawson, Valina L.
Dawson, Ted M.
Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title_full Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title_fullStr Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title_full_unstemmed Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title_short Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
title_sort inhibitors of leucine rich repeat kinase 2 (lrrk2) protect against lrrk2-models of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935926/
https://www.ncbi.nlm.nih.gov/pubmed/20729864
http://dx.doi.org/10.1038/nm.2199
work_keys_str_mv AT leebyoungdae inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT shinjooho inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT vankampenjackalina inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT petrucellileonard inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT westandrewb inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT kohanseok inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT leeyun inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT maguirezeisskathleena inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT bowerswilliamj inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT federoffhowardj inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT dawsonvalinal inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease
AT dawsontedm inhibitorsofleucinerichrepeatkinase2lrrk2protectagainstlrrk2modelsofparkinsonsdisease

Ejemplares similares