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Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats

BACKGROUND: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. METHODS: M...

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Autores principales: Park, Byoung Yoon, Park, Sang Hee, Kim, Woong Mo, Yoon, Myung Ha, Lee, Hyung Gon
Formato: Texto
Lenguaje:English
Publicado: The Korean Pain Society 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935979/
https://www.ncbi.nlm.nih.gov/pubmed/20830263
http://dx.doi.org/10.3344/kjp.2010.23.3.179
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author Park, Byoung Yoon
Park, Sang Hee
Kim, Woong Mo
Yoon, Myung Ha
Lee, Hyung Gon
author_facet Park, Byoung Yoon
Park, Sang Hee
Kim, Woong Mo
Yoon, Myung Ha
Lee, Hyung Gon
author_sort Park, Byoung Yoon
collection PubMed
description BACKGROUND: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. METHODS: Male Sprague-Dawley rats weighing 220-240 g were used in all experiments. Rats subsequently received daily intraperitoneal injections of either vincristine sulfate (0.1 ml/kg/day) or saline (0.1 ml/kg/day) over 12 days, immediately following behavioral testing. For assessment of mechanical allodynia, mechanical stimuli using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of N-methyl-D-aspartate receptors antagonist (memantine; 2.5, 5, 10 mg/kg intraperitoneal), opioid agonist (morphine; 2.5, 5, 10 mg/kg intraperitoneal) and vehicle (saline) on vicristine-induced neuropathy were evaluated. RESULTS: Mechanical allodynia developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same time. Morphine abolished the reduction in paw withdrawal threshold compared to vehicle and produced dose-responsiveness. Only the highest dose of memantine (10 mg/kg) was able to increase paw withdrawal threshold compared to vehicle. CONCLUSIONS: Systemic morphine and memantine have an antinociceptive effect on the vincristine-induced peripheral neuropathy model in rats. These results suggest morphine and memantine may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.
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spelling pubmed-29359792010-09-09 Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats Park, Byoung Yoon Park, Sang Hee Kim, Woong Mo Yoon, Myung Ha Lee, Hyung Gon Korean J Pain Original Article BACKGROUND: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. METHODS: Male Sprague-Dawley rats weighing 220-240 g were used in all experiments. Rats subsequently received daily intraperitoneal injections of either vincristine sulfate (0.1 ml/kg/day) or saline (0.1 ml/kg/day) over 12 days, immediately following behavioral testing. For assessment of mechanical allodynia, mechanical stimuli using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of N-methyl-D-aspartate receptors antagonist (memantine; 2.5, 5, 10 mg/kg intraperitoneal), opioid agonist (morphine; 2.5, 5, 10 mg/kg intraperitoneal) and vehicle (saline) on vicristine-induced neuropathy were evaluated. RESULTS: Mechanical allodynia developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same time. Morphine abolished the reduction in paw withdrawal threshold compared to vehicle and produced dose-responsiveness. Only the highest dose of memantine (10 mg/kg) was able to increase paw withdrawal threshold compared to vehicle. CONCLUSIONS: Systemic morphine and memantine have an antinociceptive effect on the vincristine-induced peripheral neuropathy model in rats. These results suggest morphine and memantine may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain. The Korean Pain Society 2010-09 2010-08-26 /pmc/articles/PMC2935979/ /pubmed/20830263 http://dx.doi.org/10.3344/kjp.2010.23.3.179 Text en Copyright © The Korean Pain Society, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Byoung Yoon
Park, Sang Hee
Kim, Woong Mo
Yoon, Myung Ha
Lee, Hyung Gon
Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title_full Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title_fullStr Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title_full_unstemmed Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title_short Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
title_sort antinociceptive effect of memantine and morphine on vincristine-induced peripheral neuropathy in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935979/
https://www.ncbi.nlm.nih.gov/pubmed/20830263
http://dx.doi.org/10.3344/kjp.2010.23.3.179
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