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RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells

Embryonic stem cells (ESCs) are capable of undergoing self-renewal, and their developmental ability is known as the stemness. Recently, microRNAs (miRNAs) as regulators have been isolated from ESCs. Although Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) are essential factors for the bio...

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Autor principal: Fujii, Yoichi R.
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936035/
https://www.ncbi.nlm.nih.gov/pubmed/20835360
http://dx.doi.org/10.2174/1874357901004010063
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author Fujii, Yoichi R.
author_facet Fujii, Yoichi R.
author_sort Fujii, Yoichi R.
collection PubMed
description Embryonic stem cells (ESCs) are capable of undergoing self-renewal, and their developmental ability is known as the stemness. Recently, microRNAs (miRNAs) as regulators have been isolated from ESCs. Although Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) are essential factors for the biogeneration of miRNA, Dicer-knockout (KO) ESCs have showed to fail to express differentiation markers and DGCR8-KO ESCs have showed to be arrest in the G1 phase. Furthermore, Dicer-KO ESCs lost the ability to epigenetically silence retroelemtns (REs). REs are expressed and transposed in ESCs, whose transcripts control expression of miRNAs, and their transposable retroelement (TE) expression is, therefore related to ESC proliferation and differentiation, suggesting that the interplay between miRNAs and REs may have a deep responsibility for the stemness including a short G1/S transition and for RE regulation in ESCs.
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spelling pubmed-29360352010-09-10 RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells Fujii, Yoichi R. Open Virol J Article Embryonic stem cells (ESCs) are capable of undergoing self-renewal, and their developmental ability is known as the stemness. Recently, microRNAs (miRNAs) as regulators have been isolated from ESCs. Although Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) are essential factors for the biogeneration of miRNA, Dicer-knockout (KO) ESCs have showed to fail to express differentiation markers and DGCR8-KO ESCs have showed to be arrest in the G1 phase. Furthermore, Dicer-KO ESCs lost the ability to epigenetically silence retroelemtns (REs). REs are expressed and transposed in ESCs, whose transcripts control expression of miRNAs, and their transposable retroelement (TE) expression is, therefore related to ESC proliferation and differentiation, suggesting that the interplay between miRNAs and REs may have a deep responsibility for the stemness including a short G1/S transition and for RE regulation in ESCs. Bentham Open 2010-05-25 /pmc/articles/PMC2936035/ /pubmed/20835360 http://dx.doi.org/10.2174/1874357901004010063 Text en © Yoichi R. Fujii; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Fujii, Yoichi R.
RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title_full RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title_fullStr RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title_full_unstemmed RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title_short RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells
title_sort rna genes: retroelements and virally retroposable micrornas in human embryonic stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936035/
https://www.ncbi.nlm.nih.gov/pubmed/20835360
http://dx.doi.org/10.2174/1874357901004010063
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