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Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression

Meta-analyses evaluating the association between the serotonin transporter polymorphism (5-HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive. We examined a gene–environment interaction on a cognitive vulnerability marker of depression, cognitive reactivity (CR) t...

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Detalles Bibliográficos
Autores principales: Antypa, N, Van der Does, A J W
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936121/
https://www.ncbi.nlm.nih.gov/pubmed/20455953
http://dx.doi.org/10.1111/j.1601-183X.2010.00593.x
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author Antypa, N
Van der Does, A J W
author_facet Antypa, N
Van der Does, A J W
author_sort Antypa, N
collection PubMed
description Meta-analyses evaluating the association between the serotonin transporter polymorphism (5-HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive. We examined a gene–environment interaction on a cognitive vulnerability marker of depression, cognitive reactivity (CR) to sad mood. A total of 250 university students of European ancestry were genotyped for the 5-HTTLPR, including SNP rs25531, a polymorphism of the long allele. Association analysis was performed for neuroticism, CR and depression diagnosis (using a self-report measure). As an environmental pathogen, self-reported history of childhood emotional abuse was measured because of its strong relationship with depression. Participants with the homozygous low expressing genotype had high CR if they had experienced childhood emotional maltreatment but low CR if they did not have such experience. This interaction was strongest on the Rumination subscale of the CR measure. The interaction was not significant with neuroticism or depression diagnosis as outcome measures. Our results show that 5-HTTLPR is related to cognitive vulnerability to depression. Our findings provide evidence for a differential susceptibility genotype rather than a vulnerability genotype, possibly because of the relatively low levels of abuse in our sample. The selection of phenotype and environmental contributor is pivotal in investigating gene–environment interactions in psychiatric disorders.
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spelling pubmed-29361212010-09-17 Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression Antypa, N Van der Does, A J W Genes Brain Behav Original Articles Meta-analyses evaluating the association between the serotonin transporter polymorphism (5-HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive. We examined a gene–environment interaction on a cognitive vulnerability marker of depression, cognitive reactivity (CR) to sad mood. A total of 250 university students of European ancestry were genotyped for the 5-HTTLPR, including SNP rs25531, a polymorphism of the long allele. Association analysis was performed for neuroticism, CR and depression diagnosis (using a self-report measure). As an environmental pathogen, self-reported history of childhood emotional abuse was measured because of its strong relationship with depression. Participants with the homozygous low expressing genotype had high CR if they had experienced childhood emotional maltreatment but low CR if they did not have such experience. This interaction was strongest on the Rumination subscale of the CR measure. The interaction was not significant with neuroticism or depression diagnosis as outcome measures. Our results show that 5-HTTLPR is related to cognitive vulnerability to depression. Our findings provide evidence for a differential susceptibility genotype rather than a vulnerability genotype, possibly because of the relatively low levels of abuse in our sample. The selection of phenotype and environmental contributor is pivotal in investigating gene–environment interactions in psychiatric disorders. Blackwell Publishing Ltd 2010-08 /pmc/articles/PMC2936121/ /pubmed/20455953 http://dx.doi.org/10.1111/j.1601-183X.2010.00593.x Text en Journal compilation © 2010 Blackwell Publishing Ltd/International Behavioural and Neural Genetics Society http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Articles
Antypa, N
Van der Does, A J W
Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title_full Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title_fullStr Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title_full_unstemmed Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title_short Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
title_sort serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936121/
https://www.ncbi.nlm.nih.gov/pubmed/20455953
http://dx.doi.org/10.1111/j.1601-183X.2010.00593.x
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