Adenoviruses with an α(v)β integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases

BACKGROUND: Colorectal cancer is often a deadly disease and cannot be cured at metastatic stage. Oncolytic adenoviruses have been considered as a new therapeutic option for treatment of refractory disseminated cancers, including colorectal cancer. The safety data has been excellent but tumor transdu...

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Detalles Bibliográficos
Autores principales: Lavilla-Alonso, Sergio, Bauerschmitz, Gerd, Abo-Ramadan, Usama, Halavaara, Juha, Escutenaire, Sophie, Diaconu, Iulia, Tatlisumak, Turgut, Kanerva, Anna, Hemminki, Akseli, Pesonen, Sari
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936307/
https://www.ncbi.nlm.nih.gov/pubmed/20727221
http://dx.doi.org/10.1186/1479-5876-8-80

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