Cargando…
Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936329/ https://www.ncbi.nlm.nih.gov/pubmed/20735825 http://dx.doi.org/10.1186/1471-2407-10-456 |
_version_ | 1782186469818892288 |
---|---|
author | Liu, Jie Song, Bao Bai, Xueli Liu, Wenjian Li, Zengjun Wang, Jialin Zheng, Yan Wang, Zhehai |
author_facet | Liu, Jie Song, Bao Bai, Xueli Liu, Wenjian Li, Zengjun Wang, Jialin Zheng, Yan Wang, Zhehai |
author_sort | Liu, Jie |
collection | PubMed |
description | BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals to PCa in a Chinese population. METHODS: We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade. RESULTS: No significant differences in allele frequency or genotype distribution were observed for any of the IL-10 SNPs between PCa patients and control subjects. Significantly higher frequencies of -1082G, -819C and -592C allele and GCC haplotype were observed, however, in early stage patients in comparison to advanced PCa patients (for -1082 G, 13.9% vs 6.1%, OR = 2.48, P = 0.005; for -819 C 40.3% vs 30.8%, OR = 1.51, P = 0.043; for -512C, 40.3% vs 30.8%, OR = 1.51, P = 0.043; and for haplotype GCC 11.1%vs 5.1%, OR = 2.66, P = 0.008, respectively). CONCLUSIONS: Our results identify that IL-10 promoter polymorphisms might not be a risk factor for PCa in Chinese cohorts, but rather incidence of polymorphisms associates with PCa grade, suggesting that IL-10 expression may impact PCa progression. |
format | Text |
id | pubmed-2936329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29363292010-09-10 Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese Liu, Jie Song, Bao Bai, Xueli Liu, Wenjian Li, Zengjun Wang, Jialin Zheng, Yan Wang, Zhehai BMC Cancer Research Article BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals to PCa in a Chinese population. METHODS: We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade. RESULTS: No significant differences in allele frequency or genotype distribution were observed for any of the IL-10 SNPs between PCa patients and control subjects. Significantly higher frequencies of -1082G, -819C and -592C allele and GCC haplotype were observed, however, in early stage patients in comparison to advanced PCa patients (for -1082 G, 13.9% vs 6.1%, OR = 2.48, P = 0.005; for -819 C 40.3% vs 30.8%, OR = 1.51, P = 0.043; for -512C, 40.3% vs 30.8%, OR = 1.51, P = 0.043; and for haplotype GCC 11.1%vs 5.1%, OR = 2.66, P = 0.008, respectively). CONCLUSIONS: Our results identify that IL-10 promoter polymorphisms might not be a risk factor for PCa in Chinese cohorts, but rather incidence of polymorphisms associates with PCa grade, suggesting that IL-10 expression may impact PCa progression. BioMed Central 2010-08-24 /pmc/articles/PMC2936329/ /pubmed/20735825 http://dx.doi.org/10.1186/1471-2407-10-456 Text en Copyright ©2010 Liu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Jie Song, Bao Bai, Xueli Liu, Wenjian Li, Zengjun Wang, Jialin Zheng, Yan Wang, Zhehai Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title | Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title_full | Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title_fullStr | Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title_full_unstemmed | Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title_short | Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese |
title_sort | association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in chinese |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936329/ https://www.ncbi.nlm.nih.gov/pubmed/20735825 http://dx.doi.org/10.1186/1471-2407-10-456 |
work_keys_str_mv | AT liujie associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT songbao associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT baixueli associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT liuwenjian associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT lizengjun associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT wangjialin associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT zhengyan associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese AT wangzhehai associationofgeneticpolymorphismsintheinterleukin10promoterwithriskofprostatecancerinchinese |