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Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese

BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing...

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Autores principales: Liu, Jie, Song, Bao, Bai, Xueli, Liu, Wenjian, Li, Zengjun, Wang, Jialin, Zheng, Yan, Wang, Zhehai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936329/
https://www.ncbi.nlm.nih.gov/pubmed/20735825
http://dx.doi.org/10.1186/1471-2407-10-456
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author Liu, Jie
Song, Bao
Bai, Xueli
Liu, Wenjian
Li, Zengjun
Wang, Jialin
Zheng, Yan
Wang, Zhehai
author_facet Liu, Jie
Song, Bao
Bai, Xueli
Liu, Wenjian
Li, Zengjun
Wang, Jialin
Zheng, Yan
Wang, Zhehai
author_sort Liu, Jie
collection PubMed
description BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals to PCa in a Chinese population. METHODS: We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade. RESULTS: No significant differences in allele frequency or genotype distribution were observed for any of the IL-10 SNPs between PCa patients and control subjects. Significantly higher frequencies of -1082G, -819C and -592C allele and GCC haplotype were observed, however, in early stage patients in comparison to advanced PCa patients (for -1082 G, 13.9% vs 6.1%, OR = 2.48, P = 0.005; for -819 C 40.3% vs 30.8%, OR = 1.51, P = 0.043; for -512C, 40.3% vs 30.8%, OR = 1.51, P = 0.043; and for haplotype GCC 11.1%vs 5.1%, OR = 2.66, P = 0.008, respectively). CONCLUSIONS: Our results identify that IL-10 promoter polymorphisms might not be a risk factor for PCa in Chinese cohorts, but rather incidence of polymorphisms associates with PCa grade, suggesting that IL-10 expression may impact PCa progression.
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spelling pubmed-29363292010-09-10 Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese Liu, Jie Song, Bao Bai, Xueli Liu, Wenjian Li, Zengjun Wang, Jialin Zheng, Yan Wang, Zhehai BMC Cancer Research Article BACKGROUND: Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals to PCa in a Chinese population. METHODS: We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade. RESULTS: No significant differences in allele frequency or genotype distribution were observed for any of the IL-10 SNPs between PCa patients and control subjects. Significantly higher frequencies of -1082G, -819C and -592C allele and GCC haplotype were observed, however, in early stage patients in comparison to advanced PCa patients (for -1082 G, 13.9% vs 6.1%, OR = 2.48, P = 0.005; for -819 C 40.3% vs 30.8%, OR = 1.51, P = 0.043; for -512C, 40.3% vs 30.8%, OR = 1.51, P = 0.043; and for haplotype GCC 11.1%vs 5.1%, OR = 2.66, P = 0.008, respectively). CONCLUSIONS: Our results identify that IL-10 promoter polymorphisms might not be a risk factor for PCa in Chinese cohorts, but rather incidence of polymorphisms associates with PCa grade, suggesting that IL-10 expression may impact PCa progression. BioMed Central 2010-08-24 /pmc/articles/PMC2936329/ /pubmed/20735825 http://dx.doi.org/10.1186/1471-2407-10-456 Text en Copyright ©2010 Liu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Jie
Song, Bao
Bai, Xueli
Liu, Wenjian
Li, Zengjun
Wang, Jialin
Zheng, Yan
Wang, Zhehai
Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title_full Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title_fullStr Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title_full_unstemmed Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title_short Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
title_sort association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in chinese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936329/
https://www.ncbi.nlm.nih.gov/pubmed/20735825
http://dx.doi.org/10.1186/1471-2407-10-456
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