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Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender

BACKGROUND: Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphol...

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Autores principales: Pereira, Thiago MC, Nogueira, Breno V, Lima, Leandro CF, Porto, Marcella L, Arruda, Jose A, Vasquez, Elisardo C, Meyrelles, Silvana S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936359/
https://www.ncbi.nlm.nih.gov/pubmed/20723257
http://dx.doi.org/10.1186/1476-511X-9-87
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author Pereira, Thiago MC
Nogueira, Breno V
Lima, Leandro CF
Porto, Marcella L
Arruda, Jose A
Vasquez, Elisardo C
Meyrelles, Silvana S
author_facet Pereira, Thiago MC
Nogueira, Breno V
Lima, Leandro CF
Porto, Marcella L
Arruda, Jose A
Vasquez, Elisardo C
Meyrelles, Silvana S
author_sort Pereira, Thiago MC
collection PubMed
description BACKGROUND: Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO) mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice. METHODS: The grade (0 to 4) of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57) mice. RESULTS: Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive) remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68) using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice. CONCLUSION: The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice.
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spelling pubmed-29363592010-09-10 Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender Pereira, Thiago MC Nogueira, Breno V Lima, Leandro CF Porto, Marcella L Arruda, Jose A Vasquez, Elisardo C Meyrelles, Silvana S Lipids Health Dis Research BACKGROUND: Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO) mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice. METHODS: The grade (0 to 4) of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57) mice. RESULTS: Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive) remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68) using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice. CONCLUSION: The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice. BioMed Central 2010-08-19 /pmc/articles/PMC2936359/ /pubmed/20723257 http://dx.doi.org/10.1186/1476-511X-9-87 Text en Copyright ©2010 Pereira et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Pereira, Thiago MC
Nogueira, Breno V
Lima, Leandro CF
Porto, Marcella L
Arruda, Jose A
Vasquez, Elisardo C
Meyrelles, Silvana S
Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title_full Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title_fullStr Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title_full_unstemmed Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title_short Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
title_sort cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936359/
https://www.ncbi.nlm.nih.gov/pubmed/20723257
http://dx.doi.org/10.1186/1476-511X-9-87
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