Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins - towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation

BACKGROUND: Mucin type O-glycosylation is one of the most common types of post-translational modifications that impacts stability and biological functions of many mammalian proteins. A large family of UDP-GalNAc polypeptide:N-acetyl-α-galactosaminyltransferases (GalNAc-Ts) catalyzes the first step o...

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Detalles Bibliográficos
Autores principales: Daskalova, Sasha M, Radder, Josiah E, Cichacz, Zbigniew A, Olsen, Sam H, Tsaprailis, George, Mason, Hugh, Lopez, Linda C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936419/
https://www.ncbi.nlm.nih.gov/pubmed/20735851
http://dx.doi.org/10.1186/1472-6750-10-62

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