Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation defects that are exacerbated under conditions of r...

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Detalles Bibliográficos
Autores principales: Chuang, Chen-Hua, Wallace, Marsha D., Abratte, Christian, Southard, Teresa, Schimenti, John C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936539/
https://www.ncbi.nlm.nih.gov/pubmed/20838603
http://dx.doi.org/10.1371/journal.pgen.1001110

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