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Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy
BACKGROUND: To define the clinical target volume (CTV) for radiotherapy in patients with hepatocellular carcinoma (HCC). METHODS: A prospective study was conducted to histologically evaluate the presence and the distance of microscopic extension (ME) for resected HCC on the basis of examination of w...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936917/ https://www.ncbi.nlm.nih.gov/pubmed/20731853 http://dx.doi.org/10.1186/1748-717X-5-73 |
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author | Wang, Weihu Feng, Xiaoli Zhang, Tao Jin, Jing Wang, Shulian Liu, Yueping Song, Yongwen Liu, Xinfan Yu, Zihao Li, Yexiong |
author_facet | Wang, Weihu Feng, Xiaoli Zhang, Tao Jin, Jing Wang, Shulian Liu, Yueping Song, Yongwen Liu, Xinfan Yu, Zihao Li, Yexiong |
author_sort | Wang, Weihu |
collection | PubMed |
description | BACKGROUND: To define the clinical target volume (CTV) for radiotherapy in patients with hepatocellular carcinoma (HCC). METHODS: A prospective study was conducted to histologically evaluate the presence and the distance of microscopic extension (ME) for resected HCC on the basis of examination of whole-mount preparations of carcinoma tissue sections. RESULTS: A total of 380 whole-mount slides prepared from tumor samples of 76 patients with HCC were examined. Patients with elevated pretreatment AFP levels exhibited higher risk of ME as compared to those with normal pretreatment AFP levels (93.9% vs. 69.8%, P < 0.01). ME positivity was 16.7% for Grade 1, 79.1% for Grade 2, and 96.3% for Grade 3 tumors (P < 0.01). The mean distance of ME was 0.0 ± 0.1 mm (range 0-0.2 mm) for Grade 1, 0.9 ± 0.9 mm (range 0-4.5 mm) for Grade 2, and 1.9 ± 1.9 mm (range 0-8.0 mm) for Grade 3 tumors (P < 0.01). CONCLUSIONS: The CTV margins for tumor Grades 1, 2, and 3 HCC, are recommended to be 0.2 mm, 4.5 mm, and 8.0 mm beyond the gross tumor margin, respectively, to account for possible ME of the tumors in all patients. |
format | Text |
id | pubmed-2936917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29369172010-09-11 Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy Wang, Weihu Feng, Xiaoli Zhang, Tao Jin, Jing Wang, Shulian Liu, Yueping Song, Yongwen Liu, Xinfan Yu, Zihao Li, Yexiong Radiat Oncol Research BACKGROUND: To define the clinical target volume (CTV) for radiotherapy in patients with hepatocellular carcinoma (HCC). METHODS: A prospective study was conducted to histologically evaluate the presence and the distance of microscopic extension (ME) for resected HCC on the basis of examination of whole-mount preparations of carcinoma tissue sections. RESULTS: A total of 380 whole-mount slides prepared from tumor samples of 76 patients with HCC were examined. Patients with elevated pretreatment AFP levels exhibited higher risk of ME as compared to those with normal pretreatment AFP levels (93.9% vs. 69.8%, P < 0.01). ME positivity was 16.7% for Grade 1, 79.1% for Grade 2, and 96.3% for Grade 3 tumors (P < 0.01). The mean distance of ME was 0.0 ± 0.1 mm (range 0-0.2 mm) for Grade 1, 0.9 ± 0.9 mm (range 0-4.5 mm) for Grade 2, and 1.9 ± 1.9 mm (range 0-8.0 mm) for Grade 3 tumors (P < 0.01). CONCLUSIONS: The CTV margins for tumor Grades 1, 2, and 3 HCC, are recommended to be 0.2 mm, 4.5 mm, and 8.0 mm beyond the gross tumor margin, respectively, to account for possible ME of the tumors in all patients. BioMed Central 2010-08-23 /pmc/articles/PMC2936917/ /pubmed/20731853 http://dx.doi.org/10.1186/1748-717X-5-73 Text en Copyright ©2010 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Wang, Weihu Feng, Xiaoli Zhang, Tao Jin, Jing Wang, Shulian Liu, Yueping Song, Yongwen Liu, Xinfan Yu, Zihao Li, Yexiong Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title | Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title_full | Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title_fullStr | Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title_full_unstemmed | Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title_short | Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy |
title_sort | prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: definition of clinical target volume for radiotherapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936917/ https://www.ncbi.nlm.nih.gov/pubmed/20731853 http://dx.doi.org/10.1186/1748-717X-5-73 |
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