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Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
The use of homologous recombination to modify genes in embryonic stem (ES) cells provides a powerful means to elucidate gene function and create disease models1. Application of this technology to engineer genes in rats has previously been impossible in the absence of germline competent ES cells in t...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937076/ https://www.ncbi.nlm.nih.gov/pubmed/20703227 http://dx.doi.org/10.1038/nature09368 |