Lineage-specific expansion of DNA-binding transcription factor families

DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved an...

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Detalles Bibliográficos
Autores principales: Charoensawan, Varodom, Wilson, Derek, Teichmann, Sarah A.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2010
Materias:
Update
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937223/
https://www.ncbi.nlm.nih.gov/pubmed/20675012
http://dx.doi.org/10.1016/j.tig.2010.06.004
Descripción
Sumario:DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved and specific DBD occurrence in diverse taxonomic lineages. By combining DBD occurrence in different species with taxonomic information, we have developed an automatic method for inferring the origins of DBD families and their specific combinations with other protein families in TFs. We found only three out of 131 (2%) DBD families shared by the three superkingdoms.

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