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Animal models and biomarkers of neuropathy in diabetic rodents

Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal mod...

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Detalles Bibliográficos
Autores principales: Shaikh, A.S., Somani, R.S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937311/
https://www.ncbi.nlm.nih.gov/pubmed/20871761
http://dx.doi.org/10.4103/0253-7613.66833
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author Shaikh, A.S.
Somani, R.S.
author_facet Shaikh, A.S.
Somani, R.S.
author_sort Shaikh, A.S.
collection PubMed
description Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes.
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spelling pubmed-29373112010-09-24 Animal models and biomarkers of neuropathy in diabetic rodents Shaikh, A.S. Somani, R.S. Indian J Pharmacol Educational Forum Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes. Medknow Publications 2010-06 /pmc/articles/PMC2937311/ /pubmed/20871761 http://dx.doi.org/10.4103/0253-7613.66833 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Educational Forum
Shaikh, A.S.
Somani, R.S.
Animal models and biomarkers of neuropathy in diabetic rodents
title Animal models and biomarkers of neuropathy in diabetic rodents
title_full Animal models and biomarkers of neuropathy in diabetic rodents
title_fullStr Animal models and biomarkers of neuropathy in diabetic rodents
title_full_unstemmed Animal models and biomarkers of neuropathy in diabetic rodents
title_short Animal models and biomarkers of neuropathy in diabetic rodents
title_sort animal models and biomarkers of neuropathy in diabetic rodents
topic Educational Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937311/
https://www.ncbi.nlm.nih.gov/pubmed/20871761
http://dx.doi.org/10.4103/0253-7613.66833
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