Cargando…
Animal models and biomarkers of neuropathy in diabetic rodents
Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal mod...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937311/ https://www.ncbi.nlm.nih.gov/pubmed/20871761 http://dx.doi.org/10.4103/0253-7613.66833 |
_version_ | 1782186557285859328 |
---|---|
author | Shaikh, A.S. Somani, R.S. |
author_facet | Shaikh, A.S. Somani, R.S. |
author_sort | Shaikh, A.S. |
collection | PubMed |
description | Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes. |
format | Text |
id | pubmed-2937311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29373112010-09-24 Animal models and biomarkers of neuropathy in diabetic rodents Shaikh, A.S. Somani, R.S. Indian J Pharmacol Educational Forum Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes. Medknow Publications 2010-06 /pmc/articles/PMC2937311/ /pubmed/20871761 http://dx.doi.org/10.4103/0253-7613.66833 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Educational Forum Shaikh, A.S. Somani, R.S. Animal models and biomarkers of neuropathy in diabetic rodents |
title | Animal models and biomarkers of neuropathy in diabetic rodents |
title_full | Animal models and biomarkers of neuropathy in diabetic rodents |
title_fullStr | Animal models and biomarkers of neuropathy in diabetic rodents |
title_full_unstemmed | Animal models and biomarkers of neuropathy in diabetic rodents |
title_short | Animal models and biomarkers of neuropathy in diabetic rodents |
title_sort | animal models and biomarkers of neuropathy in diabetic rodents |
topic | Educational Forum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937311/ https://www.ncbi.nlm.nih.gov/pubmed/20871761 http://dx.doi.org/10.4103/0253-7613.66833 |
work_keys_str_mv | AT shaikhas animalmodelsandbiomarkersofneuropathyindiabeticrodents AT somanirs animalmodelsandbiomarkersofneuropathyindiabeticrodents |