Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats

OBJECTIVES: To study the ulcer protective property of sodium cromoglycate in pylorusligated rats and the biochemical role in ulcer protection by various biochemical tests. MATERIALS AND METHODS: The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wista...

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Detalles Bibliográficos
Autores principales: Srivastava, Vivek, Viswanathaswamy, A.H.M., Mohan, Govind
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937322/
https://www.ncbi.nlm.nih.gov/pubmed/20871772
http://dx.doi.org/10.4103/0253-7613.66844
Descripción
Sumario:OBJECTIVES: To study the ulcer protective property of sodium cromoglycate in pylorusligated rats and the biochemical role in ulcer protection by various biochemical tests. MATERIALS AND METHODS: The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined. RESULTS: Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control. CONCLUSION: Sodium cromoglycate has activity equipotent to ranitidine.

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