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The Reduction Potential of the Active Site Disulfides of Human Protein Disulfide Isomerase Limits Oxidation of the Enzyme by Ero1α

Disulfide formation in newly synthesized proteins entering the mammalian endoplasmic reticulum is catalyzed by protein disulfide isomerase (PDI), which is itself thought to be directly oxidized by Ero1α. The activity of Ero1α is tightly regulated by the formation of noncatalytic disulfides, which ne...

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Detalles Bibliográficos
Autores principales:	Chambers, Joseph E., Tavender, Timothy J., Oka, Ojore B. V., Warwood, Stacey, Knight, David, Bulleid, Neil J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937950/ https://www.ncbi.nlm.nih.gov/pubmed/20657012 http://dx.doi.org/10.1074/jbc.M110.156596

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