Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro-inflammatory cytokines and subsequently involved in the production of the important mediator of inflammation, prostaglandin E(2). Nonsteroidal anti-inflammatory drugs prevent prosta...

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Detalles Bibliográficos
Autores principales: Pawelzik, Sven-Christian, Uda, Narasimha Rao, Spahiu, Linda, Jegerschöld, Caroline, Stenberg, Patric, Hebert, Hans, Morgenstern, Ralf, Jakobsson, Per-Johan
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937957/
https://www.ncbi.nlm.nih.gov/pubmed/20605783
http://dx.doi.org/10.1074/jbc.M110.114454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937957/
https://www.ncbi.nlm.nih.gov/pubmed/20605783
http://dx.doi.org/10.1074/jbc.M110.114454

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