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Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4(+) Cells in the Early Phases of IL-4-induced Th2 Differentiation

We used stable isotope labeling with 4-plex iTRAQ (isobaric tags for relative and absolute quantification) reagents and LC-MS/MS to investigate proteomic changes in the nucleus of activated human CD4(+) cells during the early stages of Th2 cell differentiation. The effects of IL-4 stimulation upon a...

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Detalles Bibliográficos
Autores principales:	Moulder, Robert, Lönnberg, Tapio, Elo, Laura L., Filén, Jan-Jonas, Rainio, Eeva, Corthals, Garry, Oresic, Matej, Nyman, Tuula A., Aittokallio, Tero, Lahesmaa, Riitta
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938108/ https://www.ncbi.nlm.nih.gov/pubmed/20467038 http://dx.doi.org/10.1074/mcp.M900483-MCP200

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