Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2–7 complex

Mcm2–7 is recruited to eukaryotic origins of DNA replication by origin recognition complex, Cdc6 and Cdt1 thereby licensing the origins. Cdc6 is essential for origin licensing during DNA replication and is readily destabilized from chromatin after Mcm2–7 loading. Here, we show that after origin lice...

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Detalles Bibliográficos
Autores principales: Kundu, Lena R., Kumata, Yuji, Kakusho, Naoko, Watanabe, Saori, Furukohri, Asako, Waga, Shou, Seki, Masayuki, Masai, Hisao, Enomoto, Takemi, Tada, Shusuke
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938227/
https://www.ncbi.nlm.nih.gov/pubmed/20421204
http://dx.doi.org/10.1093/nar/gkq262

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