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Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent

BACKGROUND: CYT997 is a novel microtubule inhibitor and vascular-disrupting agent with marked preclinical anti-tumour activity. METHODS: This phase I dose-escalation study assessed the safety, tolerability, pharmacokinetics and pharmacodynamics of CYT997 administered by continuous intravenous infusi...

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Detalles Bibliográficos
Autores principales:	Lickliter, J D, Francesconi, A B, Smith, G, Burge, M, Coulthard, A, Rose, S, Griffin, M, Milne, R, McCarron, J, Yeadon, T, Wilks, A, Cubitt, A, Wyld, D K, Vasey, P A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938266/ https://www.ncbi.nlm.nih.gov/pubmed/20733579 http://dx.doi.org/10.1038/sj.bjc.6605841

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