Relationship between hair cortisol concentrations and depressive symptoms in patients with coronary artery disease

OBJECTIVE: Concentrations of cortisol in hair, a novel marker of longer-term cortisol status, were compared in depressed versus nondepressed patients with coronary artery disease (CAD). METHODS: 20 mg hair samples of 3 cm length were collected from 121 patients attending a cardiac rehabilitation pro...

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Detalles Bibliográficos
Autores principales: Dowlati, Yekta, Herrmann, Nathan, Swardfager, Walter, Thomson, Steven, Oh, Paul I, Van Uum, Stan, Koren, Gideon, Lanctôt, Krista L
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938288/
https://www.ncbi.nlm.nih.gov/pubmed/20856603
Descripción
Sumario:OBJECTIVE: Concentrations of cortisol in hair, a novel marker of longer-term cortisol status, were compared in depressed versus nondepressed patients with coronary artery disease (CAD). METHODS: 20 mg hair samples of 3 cm length were collected from 121 patients attending a cardiac rehabilitation program, 34 of whom suffered from depressive symptoms. RESULTS: Controlling for age, gender, coronary artery bypass grafting, history of depression, and time since most recent acute coronary syndrome, cortisol concentrations (P = 0.162) did not predict severity of depression. Younger age (P = 0.003) was a significant predictor of depressive symptoms. Perceived stress was not associated with long-term cortisol concentrations (P = 0.161). CONCLUSIONS: Cortisol concentrations in hair do not predict depressive symptoms in CAD patients attending cardiac rehabilitation.

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