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Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression

OBJECTIVE: To determine the effect of adjunctive quetiapine therapy on the sleep architecture of patients with bipolar or unipolar depression. METHODS: This is a prospective, single-blind, repeated measures polysomnographic study. Sleep architecture was analyzed by overnight polysomnography, and sub...

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Autores principales: Gedge, Laura, Lazowski, Lauren, Murray, David, Jokic, Ruzica, Milev, Roumen
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938299/
https://www.ncbi.nlm.nih.gov/pubmed/20856913
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author Gedge, Laura
Lazowski, Lauren
Murray, David
Jokic, Ruzica
Milev, Roumen
author_facet Gedge, Laura
Lazowski, Lauren
Murray, David
Jokic, Ruzica
Milev, Roumen
author_sort Gedge, Laura
collection PubMed
description OBJECTIVE: To determine the effect of adjunctive quetiapine therapy on the sleep architecture of patients with bipolar or unipolar depression. METHODS: This is a prospective, single-blind, repeated measures polysomnographic study. Sleep architecture was analyzed by overnight polysomnography, and subjective sleep quality was measured using the Pittsburgh Sleep Quality Index. The Hamilton Rating Scale for Depression, Montgomery Asberg Depression Rating Scale, Young Mania Rating Scale, and Clinical Global Impression-Severity Scale were employed to quantify changes in illness severity with adjunctive quetiapine treatment. Polysomnographs and clinical measures were administered at baseline, after 2–4 days of treatment, and after 21–28 days of quetiapine treatment. The average dose of quetiapine was 155 mg, ranging from 100–200 mg. RESULTS: Adjunctive quetiapine therapy did not significantly alter sleep efficiency, sleep continuity, or Pittsburgh Sleep Quality Index scores. Respiratory Disturbance Index and percentage of total time in rapid eye movement (REM) sleep significantly decreased and the percentage of total time in non-REM sleep, and duration of Stage 2 and non-REM sleep significantly increased after 2–4 days of quetiapine treatment. Illness severity significantly decreased over time. CONCLUSIONS: Adjunctive quetiapine treatment alters sleep architecture in patients with major depressive disorder or bipolar disorder, which may partially explain its early antidepressant properties. Changes in sleep architecture are more robust and significant within two to four days of starting treatment.
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spelling pubmed-29382992010-09-20 Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression Gedge, Laura Lazowski, Lauren Murray, David Jokic, Ruzica Milev, Roumen Neuropsychiatr Dis Treat Original Research OBJECTIVE: To determine the effect of adjunctive quetiapine therapy on the sleep architecture of patients with bipolar or unipolar depression. METHODS: This is a prospective, single-blind, repeated measures polysomnographic study. Sleep architecture was analyzed by overnight polysomnography, and subjective sleep quality was measured using the Pittsburgh Sleep Quality Index. The Hamilton Rating Scale for Depression, Montgomery Asberg Depression Rating Scale, Young Mania Rating Scale, and Clinical Global Impression-Severity Scale were employed to quantify changes in illness severity with adjunctive quetiapine treatment. Polysomnographs and clinical measures were administered at baseline, after 2–4 days of treatment, and after 21–28 days of quetiapine treatment. The average dose of quetiapine was 155 mg, ranging from 100–200 mg. RESULTS: Adjunctive quetiapine therapy did not significantly alter sleep efficiency, sleep continuity, or Pittsburgh Sleep Quality Index scores. Respiratory Disturbance Index and percentage of total time in rapid eye movement (REM) sleep significantly decreased and the percentage of total time in non-REM sleep, and duration of Stage 2 and non-REM sleep significantly increased after 2–4 days of quetiapine treatment. Illness severity significantly decreased over time. CONCLUSIONS: Adjunctive quetiapine treatment alters sleep architecture in patients with major depressive disorder or bipolar disorder, which may partially explain its early antidepressant properties. Changes in sleep architecture are more robust and significant within two to four days of starting treatment. Dove Medical Press 2010-09-07 2010 /pmc/articles/PMC2938299/ /pubmed/20856913 Text en © 2010 Gedge et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Gedge, Laura
Lazowski, Lauren
Murray, David
Jokic, Ruzica
Milev, Roumen
Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_full Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_fullStr Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_full_unstemmed Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_short Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_sort effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938299/
https://www.ncbi.nlm.nih.gov/pubmed/20856913
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