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Polyclonal light chains in cerebrovascular disease

Altered membrane permeability is a hallmark of inflammation and ischemia with systemic spreading. Renal dysfunction is a risk factor for cardiovascular, cerebrovascular, and metabolic diseases. The aim of the present study was to assess proteinuria and urinary polyclonal light chains in acute stroke...

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Autores principales: Fiori, Patrizia, Luigi, Maria Giannetti, Iurato, Linda, Tammaro, Carminantonio, Esposito, Gigliola, Monaco, Antonio
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938302/
https://www.ncbi.nlm.nih.gov/pubmed/20856916
http://dx.doi.org/10.2147/NDT.S7529
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author Fiori, Patrizia
Luigi, Maria Giannetti
Iurato, Linda
Tammaro, Carminantonio
Esposito, Gigliola
Monaco, Antonio
author_facet Fiori, Patrizia
Luigi, Maria Giannetti
Iurato, Linda
Tammaro, Carminantonio
Esposito, Gigliola
Monaco, Antonio
author_sort Fiori, Patrizia
collection PubMed
description Altered membrane permeability is a hallmark of inflammation and ischemia with systemic spreading. Renal dysfunction is a risk factor for cardiovascular, cerebrovascular, and metabolic diseases. The aim of the present study was to assess proteinuria and urinary polyclonal light chains in acute stroke and chronic cerebrovascular disease compared with other neurologic diseases. Our results showed significantly increased levels of urinary polyclonal light chains in cerebrovascular disease compared with other neurologic diseases. The highest values of urinary polyclonal κ chains were found in acute stroke compared with chronic cerebrovascular disease and other neurologic diseases, while the level of λ chains was mainly increased in chronic cerebrovascular diseases. The shift to chronic renal failure seems to be signaled by a decreased polyclonal light chain/creatinemia ratio. The absence of a significant correlation with blood pressure and other seric parameters suggests that polyclonal light chains are an early marker of reversible vascular impairment with renal dysfunction before progression to irreversible renal failure and need for dialysis and/or intensive care.
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spelling pubmed-29383022010-09-20 Polyclonal light chains in cerebrovascular disease Fiori, Patrizia Luigi, Maria Giannetti Iurato, Linda Tammaro, Carminantonio Esposito, Gigliola Monaco, Antonio Neuropsychiatr Dis Treat Original Research Altered membrane permeability is a hallmark of inflammation and ischemia with systemic spreading. Renal dysfunction is a risk factor for cardiovascular, cerebrovascular, and metabolic diseases. The aim of the present study was to assess proteinuria and urinary polyclonal light chains in acute stroke and chronic cerebrovascular disease compared with other neurologic diseases. Our results showed significantly increased levels of urinary polyclonal light chains in cerebrovascular disease compared with other neurologic diseases. The highest values of urinary polyclonal κ chains were found in acute stroke compared with chronic cerebrovascular disease and other neurologic diseases, while the level of λ chains was mainly increased in chronic cerebrovascular diseases. The shift to chronic renal failure seems to be signaled by a decreased polyclonal light chain/creatinemia ratio. The absence of a significant correlation with blood pressure and other seric parameters suggests that polyclonal light chains are an early marker of reversible vascular impairment with renal dysfunction before progression to irreversible renal failure and need for dialysis and/or intensive care. Dove Medical Press 2010-09-07 2010 /pmc/articles/PMC2938302/ /pubmed/20856916 http://dx.doi.org/10.2147/NDT.S7529 Text en © 2010 Fiori et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Fiori, Patrizia
Luigi, Maria Giannetti
Iurato, Linda
Tammaro, Carminantonio
Esposito, Gigliola
Monaco, Antonio
Polyclonal light chains in cerebrovascular disease
title Polyclonal light chains in cerebrovascular disease
title_full Polyclonal light chains in cerebrovascular disease
title_fullStr Polyclonal light chains in cerebrovascular disease
title_full_unstemmed Polyclonal light chains in cerebrovascular disease
title_short Polyclonal light chains in cerebrovascular disease
title_sort polyclonal light chains in cerebrovascular disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938302/
https://www.ncbi.nlm.nih.gov/pubmed/20856916
http://dx.doi.org/10.2147/NDT.S7529
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