Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights int...

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Detalles Bibliográficos
Autores principales: Bugge, Anne, Mandrup, Susanne
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938449/
https://www.ncbi.nlm.nih.gov/pubmed/20862367
http://dx.doi.org/10.1155/2010/169506
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author Bugge, Anne
Mandrup, Susanne
author_facet Bugge, Anne
Mandrup, Susanne
author_sort Bugge, Anne
collection PubMed
description The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.
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spelling pubmed-29384492010-09-22 Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation Bugge, Anne Mandrup, Susanne PPAR Res Review Article The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1. Hindawi Publishing Corporation 2010 2010-08-31 /pmc/articles/PMC2938449/ /pubmed/20862367 http://dx.doi.org/10.1155/2010/169506 Text en Copyright © 2010 A. Bugge and S. Mandrup. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bugge, Anne
Mandrup, Susanne
Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_full Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_fullStr Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_full_unstemmed Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_short Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_sort molecular mechanisms and genome-wide aspects of ppar subtype specific transactivation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938449/
https://www.ncbi.nlm.nih.gov/pubmed/20862367
http://dx.doi.org/10.1155/2010/169506
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