Cargando…
E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis
Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-deri...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938478/ https://www.ncbi.nlm.nih.gov/pubmed/20399121 http://dx.doi.org/10.1016/j.immuni.2010.03.017 |
_version_ | 1782186626059862016 |
---|---|
author | Siddiqui, Karima R.R. Laffont, Sophie Powrie, Fiona |
author_facet | Siddiqui, Karima R.R. Laffont, Sophie Powrie, Fiona |
author_sort | Siddiqui, Karima R.R. |
collection | PubMed |
description | Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. |
format | Text |
id | pubmed-2938478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29384782010-10-13 E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis Siddiqui, Karima R.R. Laffont, Sophie Powrie, Fiona Immunity Article Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. Cell Press 2010-04-23 /pmc/articles/PMC2938478/ /pubmed/20399121 http://dx.doi.org/10.1016/j.immuni.2010.03.017 Text en © 2010 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Article Siddiqui, Karima R.R. Laffont, Sophie Powrie, Fiona E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title | E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title_full | E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title_fullStr | E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title_full_unstemmed | E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title_short | E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis |
title_sort | e-cadherin marks a subset of inflammatory dendritic cells that promote t cell-mediated colitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938478/ https://www.ncbi.nlm.nih.gov/pubmed/20399121 http://dx.doi.org/10.1016/j.immuni.2010.03.017 |
work_keys_str_mv | AT siddiquikarimarr ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT laffontsophie ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT powriefiona ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis |